Welcome to Yilong Zhou lab

Zhou, Y., Shvedunova, M., & Akhtar, A. (2025). Protocol to isolate stress granules in HeLa cells using fluorescence-activated non-membrane condensate isolation. STAR Protocols, 6(3), 103987.

Zhou, Y., Panhale, A., Shvedunova, M., Balan, M., Gomez-Auli, A., Holz, H., Seyfferth, J., Helmstädter, M., Kayser, S., Zhao, Y., Erdogdu, N. U., Grzadzielewska, I., Mittler, G., Manke, T., & Akhtar, A. (2024). RNA damage compartmentalization by DHX9 stress granules. Cell, 187(7):1701-1718.e28. 

Wang, F., Zhao, M., Chang, B., Zhou, Y., Wu, X., Ma, M., Liu, S., Cao, Y., Zheng, M., Dang, Y., Xu, J., Chen, L., Liu, T., Tang, F., Ren, Y., Xu, Z., Mao, Z., Huang, K., Luo, M., … Ge, B. (2022).  Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. Molecular Cell, 82(11), 2032–2049.e7. 

Wang, L.*, Zhou, Y.*, Chen, Z.*, Sun, L., Wu, J., Li, H., Liu, F., Wang, F., Yang, C., Yang, J., Leng, Q., Zhang, Q., Xu, A., Shen, L., Sun, J., Wu, D., Fang, C., Lu, H., Yan, D., & Ge, B. (2019). PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1. Nature Communications, 10(1), 746. (co-first author)

Wang, L., Liu, Z., Wang, J., Liu, H., Wu, J., Tang, T., Li, H., Yang, H., Qin, L., Ma, D., Chen, J., Liu, F., Wang, P., Zheng, R., Song, P., Zhou, Y., Cui, Z., Wu, X., Huang, X., … Ge, B. (2019).  Oxidization of TGFβ-activated kinase by MPT53 is required for immunity to Mycobacterium tuberculosis. Nature Microbiology, 4(8), 1378–1388.

Liu, H., Zhang, H., Wu, X., Ma, D., Wu, J., Wang, L., Jiang, Y., Fei, Y., Zhu, C., Tan, R., Jungblut, P., Pei, G., Dorhoi, A., Yan, Q., Zhang, F., Zheng, R., Liu, S., Liang, H., Zhou, Y., … Ge, B. (2018). Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature, 563(7729), 131–136.

Liu, F., Chen, J., Wang, P., Li, H., Zhou, Y., Liu, H., Liu, Z., Zheng, R., Wang, L., Yang, H., Cui, Z., Wang, F., Huang, X., Wang, J., Sha, W., Xiao, H., & Ge, B. (2018). MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy. Nature Communications, 9(1), 4295.

Zheng, R., Liu, H., Zhou, Y., Yan, D., Chen, J., Ma, D., Feng, Y., Qin, L., Liu, F., Huang, X., Wang, J., & Ge, B. (2018). Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation. The Journal of Infectious Diseases, 218(2), 312–323.

Zhou, Y., He, C., Wang, L., & Ge, B. (2017). Post-translational regulation of antiviral innate signaling. European Journal of Immunology, 47(9), 1414–1426.

He, C., Zhou, Y., Liu, F., Liu, H., Tan, H., Jin, S., Wu, W., & Ge, B. (2017). Bacterial Nucleotidyl Cyclase Inhibits the Host Innate Immune Response by Suppressing TAK1 Activation. Infection and Immunity, 85(9).

Zhou, Y., He, C., Yan, D., Liu, F., Liu, H., Chen, J., Cao, T., Zuo, M., Wang, P., Ge, Y., Lu, H., Tong, Q., Qin, C., Deng, Y., & Ge, B. (2016). The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3. Nature Immunology, 17(4), 397–405.

Liang, D., Liu, F., Chen, J., He, X., Zhou, Y., Ge, B., & Luo, L. (2016). Porphyromonas gingivalis infected macrophages upregulate CD36 expression via ERK/NF-κB pathway. Cellular Signalling, 28(9), 1292–1303.

Bai, W., Liu, H., Ji, Q., Zhou, Y., Liang, L., Zheng, R., Chen, J., Liu, Z., Yang, H., Zhang, P., Kaufmann, S. H. E., & Ge, B. (2014). TLR3 regulates mycobacterial RNA-induced IL-10 production through the PI3K/AKT signaling pathway. Cellular Signalling, 26(5), 942–950.