RNA is transcribed, processed, exported, translated and degraded within cells, a dynamic process shaped by various RNA-binding proteins, membrane organelles, and biomolecular condensates.
Our lab investigates the dynamics of RNA flux, focusing on understanding RNA damage response, RNA-Protein interactions and RNA-protein condensates in cancer. We aim to uncover RNA-related disease mechanisms and identify therapeutic RNA targets.
Our approach spans molecular to animal models, integrating advanced technologies such as deep sequencing, mass spectrometry, phase separation assays, FLASH and our self-developed "FANCI" method.